| Eastern Conference | Prt | Punti | Reti | Diff | v | p | s | |
|---|---|---|---|---|---|---|---|---|
| 1. | Cincinnati FC | 34 | 69 | 57:39 | 18 | 20 | 9 | 5 |
| 2. | Orlando City | 34 | 63 | 55:39 | 16 | 18 | 9 | 7 |
| 3. | Columbus Crew | 34 | 57 | 67:46 | 21 | 16 | 9 | 9 |
| 4. | Philadelphia Union | 34 | 55 | 57:41 | 16 | 15 | 10 | 9 |
| 5. | New England Revolution | 34 | 55 | 58:46 | 12 | 15 | 10 | 9 |
| 6. | Atlanta United FC | 34 | 51 | 66:53 | 13 | 13 | 12 | 9 |
| 7. | Nashville SC | 34 | 49 | 39:32 | 7 | 13 | 10 | 11 |
| 8. | New York Red Bulls | 34 | 43 | 36:39 | -3 | 11 | 10 | 13 |
| 9. | Charlotte FC | 34 | 43 | 45:52 | -7 | 10 | 13 | 11 |
| 10. | New York City FC | 34 | 41 | 35:39 | -4 | 9 | 14 | 11 |
| 11. | CF Montreal | 34 | 41 | 36:52 | -16 | 12 | 5 | 17 |
| 12. | D.C. United | 34 | 40 | 45:49 | -4 | 10 | 10 | 14 |
| 13. | Chicago Fire | 34 | 40 | 39:51 | -12 | 10 | 10 | 14 |
| 14. | Inter Miami CF | 34 | 34 | 41:54 | -13 | 9 | 7 | 18 |
| 15. | Toronto FC | 34 | 22 | 26:59 | -33 | 4 | 10 | 20 |
| Western Conference | Prt | Punti | Reti | Diff | v | p | s | |
|---|---|---|---|---|---|---|---|---|
| 1. | St. Louis City SC | 34 | 56 | 62:45 | 17 | 17 | 5 | 12 |
| 2. | Seattle Sounders | 34 | 53 | 41:32 | 9 | 14 | 11 | 9 |
| 3. | Los Angeles FC | 34 | 52 | 54:39 | 15 | 14 | 10 | 10 |
| 4. | Houston Dynamo | 34 | 51 | 51:38 | 13 | 14 | 9 | 11 |
| 5. | Real Salt Lake | 34 | 50 | 48:50 | -2 | 14 | 8 | 12 |
| 6. | Vancouver Whitecaps | 34 | 48 | 55:48 | 7 | 12 | 12 | 10 |
| 7. | FC Dallas | 34 | 46 | 41:37 | 4 | 11 | 13 | 10 |
| 8. | Sporting Kansas City | 34 | 44 | 48:51 | -3 | 12 | 8 | 14 |
| 9. | San Jose Earthquakes | 34 | 44 | 39:43 | -4 | 10 | 14 | 10 |
| 10. | Portland Timbers | 34 | 43 | 46:58 | -12 | 11 | 10 | 13 |
| 11. | Minnesota United FC | 34 | 41 | 46:51 | -5 | 10 | 11 | 13 |
| 12. | Austin FC | 34 | 39 | 49:55 | -6 | 10 | 9 | 15 |
| 13. | Los Angeles Galaxy | 34 | 36 | 51:67 | -16 | 8 | 12 | 14 |
| 14. | Colorado Rapids | 34 | 27 | 26:54 | -28 | 5 | 12 | 17 |